Nkulu Ntanda Ntambo was born on December 27, 1947, at Kailo in Zaire. He is married to Nshimba Nkulu; they have eight children (three boys and five girls). His father, Ntambo, is deceased, but his mother, Kahole Julienne, is still alive. He has been a Christian since childhood. Bishop Ntambo finished his six years of elementary school in Kabongo. He went to secondary school in Lubumbashi for six years. Then he went to seminary for four years in Mulungwishi. He has a Master of Divinity degree from Nairobi International School of Theology in Nairobi, Kenya. He has held positions as an elementary school teacher (1967 1972), senior pastor at the parish in Lubudi (1976 1977), Superintendent of the Bukama-Lubudi District (1977 1982), bishop's secretary (1982 1983), District Superintendent of Kamina (1987 1989), Christian education director, North Shaba (1987 1993), and senior director at Kamina-Ville UMC (1992). Bishop Ntambo worked as Assistant Legal Representative of North Shaba for 16 years (1977 1993).

He occupied the following positions: executive committee vice president; secretary for Swahili-speaking people at the North Shaba Annual Conference; General Board of Global Ministries director; interpreter at the 1992 General Conference in Louisville; chairperson of the North Shaba Aviation Committee, Construction Committee, Ordained Ministry Committee; international person in mission in the country of Burundi (from 1993 on, he served as D.S., supervisor, and spiritual coordinator for refugees). This year he was the North Shaba delegation leader for the Central Conference at Wembo-Nyama. Bishop Ntambo planted about 157 churches in the region of Bukama and Lubudi. He opened two congregations in Nairobi. During his ministry he visited the following countries in order to fulfill his tasks: Zimbabwe, Kenya, Uganda, Tanzania, Somalia, Senegal, Zambia, U.S.A., Israel, Angola, Gambia, and South Africa.